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Human OSMR ELISA Kit

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  • Alternative name

    Human interleukin-31 receptor subunit beta ELISA Kit;Human IL-31 receptor subunit beta ELISA Kit;Human IL-31R subunit beta ELISA Kit;Human IL-31R-beta ELISA Kit;Human IL-31RB ELISA Kit;Human OSMRB ELISA Kit;Human PLCA1 ELISA Kit;Human oncostatin M receptor ELISA Kit;Human oncostatin-M-specific receptor subunit beta ELISA Kit;Human oncostatin-M specific receptor beta subunit ELISA Kit;
  • Catalog
    E019469
  • species
    Human
  • GeneOSMR
  • SpecificityThe Human IL-31RB ELISA Kit allows for the detection and quantification of endogenous levels of natural and/or recombinant Human IL-31RB proteins within the range of 312.5 pg/ml - 20000 pg/ml.
  • SamplesSerum, Plasma , tissue homogenates,Cell culture supernates,Other biological fluids.
  • Sensitivity80 pg/ml.
  • Intended UseHuman OSMR ELISA Kit allows for the in vitro quantitative determination of OSMR , concentrations in serum, Plasma , tissue homogenates and Cell culture supernates and Other biological fluids.
  • StorageStore the whole ELISA kit at 4℃
  • Product Description
    specifical    Principle of the Assay||The Human IL-31RB ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of Human IL-31RB in Cell Culture Supernatants, Serum, Plasma. This assay employs an antibody specific for Human IL-31RB coated on a 96-well plate. Standards and samples are pipetted into the wells and IL-31RB present in a sample is bound to the wells by the immobilized antibody. The wells are washed and biotinylated anti-Human IL-31RB antibody is added. After washing away unbound biotinylated antibody, HRP-conjugated streptavidin is pipetted to the wells. The wells are again washed, a TMB substrate solution is added to the wells and color develops in proportion to the amount of IL-31RB bound. The Stop Solution changes the color from blue to yellow, and the intensity of the color is measured at 450 nm. Background/Introduction: Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with the leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. OSMR is an alternative subunit (for an OSM receptor complex (a heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF.Oncostatin M is a member of the IL6 family of cytokines. Functional receptors for IL6 family cytokines are multisubunit complexes involving members of the hematopoietin receptor superfamily. Many IL6 cytokines utilize gp130 as a common receptor subunit. OSM binds to the gp130 receptor subunit and, in association with the leukemia inhibitory factor receptor, induces a proliferative response in permissive cells. OSMR is an alternative subunit (for an OSM receptor complex (a heterodimer of gp130 and OSMR) that is activated by OSM but not by LIF.
  • Human Oncostatin-M-specific receptor subunit beta Protein information
  • Uniprot ID OSMR_HUMAN
  • Uniprot AC Q99650; Q6P4E8; Q96QJ6;
  • UniGene Hs.120658; Hs.658389;
  • GeneID 9180
  • KEGG hsa:9180;
  • Human Oncostatin-M-specific receptor subunit beta Protein SEQUENCE

  • SEQUENCE 979 AA; 110509 MW; 179852CA3D90D9EF CRC64;

    MALFAVFQTT FFLTLLSLRT YQSEVLAERL PLTPVSLKVS TNSTRQSLHL

    QWTVHNLPYH QELKMVFQIQ ISRIETSNVI WVGNYSTTVK WNQVLHWSWE

    SELPLECATH FVRIKSLVDD AKFPEPNFWS NWSSWEEVSV QDSTGQDILF

    VFPKDKLVEE GTNVTICYVS RNIQNNVSCY LEGKQIHGEQ LDPHVTAFNL

    NSVPFIRNKG TNIYCEASQG NVSEGMKGIV LFVSKVLEEP KDFSCETEDF

    KTLHCTWDPG TDTALGWSKQ PSQSYTLFES FSGEKKLCTH KNWCNWQITQ

    DSQETYNFTL IAENYLRKRS VNILFNLTHR VYLMNPFSVN FENVNATNAI

    MTWKVHSIRN NFTYLCQIEL HGEGKMMQYN VSIKVNGEYF LSELEPATEY

    MARVRCADAS HFWKWSEWSG QNFTTLEAAP SEAPDVWRIV SLEPGNHTVT

    LFWKPLSKLH ANGKILFYNV VVENLDKPSS SELHSIPAPA NSTKLILDRC

    SYQICVIANN SVGASPASVI VISADPENKE VEEERIAGTE GGFSLSWKPQ

    PGDVIGYVVD WCDHTQDVLG DFQWKNVGPN TTSTVISTDA FRPGVRYDFR

    IYGLSTKRIA CLLEKKTGYS QELAPSDNPH VLVDTLTSHS FTLSWKDYST

    ESQPGFIQGY HVYLKSKARQ CHPRFEKAVL SDGSECCKYK IDNPEEKALI

    VDNLKPESFY EFFITPFTSA GEGPSATFTK VTTPDEHSSM LIHILLPMVF

    CVLLIMVMCY LKSQWIKETC YPDIPDPYKS SILSLIKFKE NPHLIIMNVS

    DCIPDAIEVV SKPEGTKIQF LGTRKSLTET ELTKPNYLYL LPTEKNHSGP

    GPCICFENLT YNQAASDSGS CGHVPVSPKA PSMLGLMTSP ENVLKALEKN

    YMNSLGEIPA GETSLNYVSQ LASPMFGDKD SLPTNPVEAP HCSEYKMQMA

    VSLRLALPPP TENSSLSSIT LLDPGEHYC

  • UCSC uc003jlm.2; human. [Q99650-1];



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