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Alternative name
ESTRB, NR3A2 antibody
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Catalog
A002867
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityMonoclonal Antibody
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Host Mouse
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Species ReactivityHuman,Mouse
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Applications Tested/SuitableELISA,WB
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PurificationProtein A+G purification
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Immunogenestrogen receptor 2 (ER beta)
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Recommended dilutionWB : 1:1000-1:10000
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Product Description specificalNuclear hormone receptor. Binds estrogens with an affinity similar to that of ESR1, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner (PubMed:20074560). Isoform beta-cx lacks ligand binding ability and has no or only very low ere binding activity resulting in the loss of ligand-dependent transactivation ability. DNA-binding by ESR1 and ESR2 is rapidly lost at 37 degrees Celsius in the absence of ligand while in the presence of 17 beta-estradiol and 4-hydroxy-tamoxifen loss in DNA-binding at elevated temperature is more gradual.
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Gene nameESR2
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Uniprot IDQ92731
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Observed M.W.50 kDa
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