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Alternative name
INRF2, KIAA0132, KLHL19 antibody
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Catalog
A004517
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityMonoclonal Antibody
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Host Mouse
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Species ReactivityHuman,Rat
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Applications Tested/SuitableELISA,IHC,WB
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PurificationProtein A+G purification
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Immunogenkelch-like ECH-associated protein 1
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IHCImmunohistochemistry of paraffin-embedded human pancreas cancer using A004517(KEAP1 antibody) at dilution of 1:100
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Western BlotHeLa cells were subjected to SDS PAGE followed by western blot with A004517(KEAP1 antibody) at dilution of 1:500
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Recommended dilutionWB : 1:1000-1:10000
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Product Description specificalActs as a substrate adapter protein for the E3 ubiquitin ligase complex formed by CUL3 and RBX1 and targets NFE2L2/NRF2 for ubiquitination and degradation by the proteasome, thus resulting in the suppression of its transcriptional activity and the repression of antioxidant response element-mediated detoxifying enzyme gene expression. Retains NFE2L2/NRF2 and may also retain BPTF in the cytosol. Targets PGAM5 for ubiquitination and degradation by the proteasome.
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Gene nameKEAP1
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Uniprot IDQ14145
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Observed M.W.55-70 kDa
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