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Alternative name
H731 antibody
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Catalog
A006240
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityMonoclonal Antibody
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Host Mouse
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Species ReactivityHuman
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Applications Tested/SuitableELISA,WB,IHC
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PurificationProtein A+G purification
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Immunogenprogrammed cell death 4 (neoplastic transformation inhibitor)
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IHCImmunohistochemistry of paraffin-embedded human breast cancer slide using A006240( PDCD4 Antibody) at dilution of 1:50
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Western BlotHeLa cells were subjected to SDS PAGE followed by western blot with A006240( PDCD4 Antibody) at dilution of 1:4000
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Recommended dilutionWB : 1:1000-1:10000
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Product Description specificalInhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA (By similarity).
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Gene namePDCD4
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Uniprot IDQ53EL6
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Observed M.W.54-64 kDa
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