-
Alternative name
APRF antibody
-
Catalog
A008300
-
Size100μg
-
Formliquid
-
Purity≥95% as determined by SDS-PAGE
-
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
-
ClonalityMonoclonal Antibody
-
Host Mouse
-
Species ReactivityHuman,Mouse , Rat
-
Applications Tested/SuitableELISA,WB,IHC,IF,IP
-
PurificationProtein A+G purification
-
Immunogensignal transducer and activator of transcription 3 (acute-phase response factor)
-
IHCImmunohistochemistry of paraffin-embedded human cervical cancer tissue slide using A008300( STAT3 Antibody) at dilution of 1:400 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
-
Western BlotWestern blot analysis of STAT3 in various cell lines using Fine Test antibody A008300
-
Recommended dilutionWB : 1:200-1:2000
-
Product Description specificalSignal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF, LEP and other growth factors. Once activated, recruits coactivators, such as NCOA1 or MED1, to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)- responsive elements identified in the promoters of various acute- phase protein genes. Activated by IL31 through IL31RA. Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase, such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production, body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity.
-
Gene nameSTAT3
-
Uniprot IDP40763
-
Observed M.W.88 kDa
-