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Alternative name
ESP 2, HED 2, ZYX, zyxin, Zyxin 2 antibody
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Catalog
A009765
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityMonoclonal Antibody
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Host Mouse
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Species ReactivityHuman,Mouse
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Applications Tested/SuitableELISA,WB,IHC,IF
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PurificationProtein A+G purification
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Immunogenzyxin
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IHCImmunohistochemistry of paraffin-embedded human kidney slide using A009765( ZYX Antibody) at dilution of 1:50
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Western BlotHeLa cells were subjected to SDS PAGE followed by western blot with A009765(ZYX antibody) at dilution of 1:1000
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Recommended dilutionWB:1:500-1:5000;IHC:1:20-1:200;IF:1:20-1:200
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Product Description specificalFocal adhesions are actin-rich structures that enable cells to adhere to the extracellular matrix and at which protein complexes involved in signal transduction assemble. Zyxin (ZYX) is a zinc-binding phosphoprotein that concentrates at focal adhesions and along the actin cytoskeleton. Zyxin has an N-terminal proline-rich domain and three LIM domains in its C-terminal half. The proline-rich domain may interact with SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein binding. Zyxin may function as a messenger in the signal transduction pathway that mediates adhesion-stimulated changes in gene expression and may modulate the cytoskeletal organization of actin bundles.
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Gene nameZYX
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locationCell junction,Cytoplasm,Cytoskeleton,Nucleus
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Uniprot IDQ15942
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Calculated M.W.80kDa
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Observed M.W.78kd
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