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Alternative name
Apoptotic cysteine protease, Apoptotic protease Mch 5, Casp 8, CASP8, Caspase 8, Caspase 8/p18, Caspase8, FADD like ICE, FLICE, ICE like apoptotic protease 5, MACH, MCH5 antibody
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Catalog
A001293
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman
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Applications Tested/SuitableELISA,WB,IHC,IP,IF
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PurificationImmunogen affinity purified
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Immunogencaspase 8, apoptosis-related cysteine peptidase
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IHCImmunohistochemistry of paraffin-embedded human lymphoma using A001293(CASP8 antibody) at dilution of 1:50
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Western BlotHepG2 cells were subjected to SDS PAGE followed by western blot with A001293(CASP8 antibody) at dilution of 1:1000
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Recommended dilutionWB:1:200-1:2000;IP:1:200-1:2000;IHC:1:50-1:100;IF:1:10-1:100
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Product Description specificalCaspase 8, also named as MCH5, MACH, FLICE, and CAP4, belongs to the peptidase C14A family. It may participate in the GZMB apoptotic pathways and functions as an upstream regulator in a-bisabolol-induced apoptosis. Caspase 8 catalyzes an essential intermediate step in the ubiquitination and proteasome-mediated degradation of IRF3(PMID:21816816 ). It may control diabetic embryopathy-associated apoptosis via Caspase 8 is expressed as nine isoforms by alternative splicing with the molecular mass from 26 kDa to 62 kDa. 66093-1-AP can recognize pro- and cleaved-caspase 8.
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Gene nameCASP8
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Uniprot IDQ14790
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Calculated M.W.30-60kDa
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Observed M.W.50-55 kDa,25-32 kDa
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