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Alternative name
CBX4, Chromobox protein homolog 4, E3 SUMO protein ligase CBX4, hPC2, NBP16, PC2, Polycomb 2 homolog antibody
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Catalog
A001331
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,IF,WB
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PurificationImmunogen affinity purified
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Immunogenchromobox homolog 4 (Pc class homolog, Drosophila)
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Recommended dilutionWB : N/A
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Product Description specificalE3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. Involved in the sumoylation of HNRNPK, a p53/TP53 transcriptional coactivator, hence indirectly regulates p53/TP53 transcriptional activation resulting in p21/CDKN1A expression. Monosumoylates ZNF131._x000D_Component of a Polycomb group (PcG) multiprotein PRC1- like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.
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Gene nameCBX4
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Uniprot IDO00257
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Observed M.W.~75 kDa
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