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Alternative name
ADAM 17, ADAM17, CD156b, cSVP, Snake venom like protease, TACE, TNF alpha convertase, TNF alpha converting enzyme antibody
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Catalog
A000138
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman
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Applications Tested/SuitableELISA,WB
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PurificationImmunogen affinity purified
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ImmunogenADAM metallopeptidase domain 17
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IHCImmunohistochemistry of paraffin-embedded human pancreas cancer tissue slide using A000138( ADAM17 Antibody) at dilution of 1:200
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Western BlotU-937 cells were subjected to SDS PAGE followed by western blot with A000138( ADAM17 Antibody) at dilution of 1:600
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Recommended dilutionWB :1:200-1:2000;IHC:1:20-1:200
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Product Description specificalCleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2.
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Gene nameADAM17
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locationMembrane
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Uniprot IDP78536
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Calculated M.W.93kDa,observed 75kDa
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Observed M.W.75 kDa
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