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Alternative name
IC53 , antibody
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Catalog
A001560
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC,IF,FC
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PurificationImmunogen affinity purified
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ImmunogenCDK5 regulatory subunit associated protein 3
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IHCImmunohistochemistry of paraffin-embedded human pancreas cancer using A001560(CDK5RAP3 antibody) at dilution of 1:100
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Western BlotHeLa cells were subjected to SDS PAGE followed by western blot with A001560(CDK5RAP3 antibody) at dilution of 1:2000
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Recommended dilutionWB : 1:1000-1:10000
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Product Description specificalProbable tumor suppressor initially identified as a CDK5R1 interactor controlling cell proliferation (PubMed:12054757, PubMed:12737517). Negatively regulates NF-kappa-B-mediated gene transcription through the control of RELA phosphorylation (PubMed:17785205, PubMed:20228063). Also regulates mitotic G2/M transition checkpoint and mitotic G2 DNA damage checkpoint (PubMed:15790566, PubMed:19223857). Through its interaction with CDKN2A/ARF and MDM2 may induce MDM2-dependent p53/TP53 ubiquitination, stabilization and activation in the nucleus, thereby promoting G1 cell cycle arrest and inhibition of cell proliferation (PubMed:16173922). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). May also play a role in the rupture of the nuclear envelope during apoptosis (PubMed:23478299). May regulate MAPK14 activity by regulating its dephosphorylation by PPM1D/WIP1 (PubMed:21283629). _x000D_(Microbial infection) May be negatively regulated by hepatitis B virus large envelope protein mutant pre-s2 to promote mitotic entry.
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Gene nameCDK5RAP3
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Uniprot IDQ96JB5
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Observed M.W.65 kDa
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