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Alternative name
centrosomal protein 63kDa, Centrosomal protein of 63 kDa, CEP63, FLJ13386 antibody
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Catalog
A001606
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IF,IP,IHC
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PurificationImmunogen affinity purified
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Immunogencentrosomal protein 63kDa
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IHCImmunohistochemistry of paraffin-embedded human tonsillitis tissue slide using A001606( CEP63 Antibody) at dilution of 1:50
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Western Blothuman placenta tissue were subjected to SDS PAGE followed by western blot with A001606(CEP63 antibody) at dilution of 1:800
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalRequired for normal spindle assembly. Plays a key role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and WDR62 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication. Reported to be required for centrosomal recruitment of CEP152; however, this function has been questioned (PubMed:21983783, PubMed:26297806). Also recruits CDK1 to centrosomes (PubMed:21406398). Plays a role in DNA damage response. Following DNA damage, such as double-strand breaks (DSBs), is removed from centrosomes; this leads to the inactivation of spindle assembly and delay in mitotic progression (PubMed:21406398).
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Gene nameCEP63
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Uniprot IDQ96MT8
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Observed M.W.57-75kd
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