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Alternative name
Adenylosuccinase, adenylosuccinate lyase, ADSL, AMPS, ASASE, ASL antibody
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Catalog
A000161
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC,IF,FC
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PurificationImmunogen affinity purified
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Immunogenadenylosuccinate lyase
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IHCImmunohistochemistry of paraffin-embedded human liver cancer using A000161(ADSL antibody) at dilution of 1:50
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Western BlotHeLa cells were subjected to SDS PAGE followed by western blot with A000161(ADSL antibody) at dilution of 1:400
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Recommended dilutionWB :1:500-1:5000;IHC:1:20-1:200;IF:1:10-1:100
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Product Description specificalADSL(adenylosuccinate lyase) is also named as AMPS, ASase, ASL and belongs to the lyase 1 family. It is an enzyme involved in 2 pathways of purine nucleotide metabolism and catalyzes cleavage of succinyl groups to yield fumarate(PMID:18524658). Defects in ADSL are the cause of adenylosuccinase deficiency (ADSL deficiency). In humans, mutations in ADSL lead to an inborn error of metabolism originally characterized by developmental delay, often with autistic features(PMID:20884265)..The ADSL enzymatic activity is reduced in lymphocytes and red blood cells of the patient with severe psychomotor retardation(PMID:9545543). It has 2 isoforms produced by alternative splicing.
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Gene nameADSL
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locationcytosol
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Uniprot IDP30566
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Calculated M.W.55kDa
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Observed M.W.55 kDa
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