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Alternative name
CHMP2.5, CHMP2B, chromatin modifying protein 2B, DKFZp564O123, DMT1, hVps2 2, VPS2 2, VPS2B antibody
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Catalog
A001659
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IF,IHC
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PurificationImmunogen affinity purified
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Immunogenchromatin modifying protein 2B
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IHCImmunohistochemistry of paraffin-embedded human liver using A001659(CHMP2B antibody) at dilution of 1:50
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Western BlotSH-SY5Y cells were subjected to SDS PAGE followed by western blot with A001659(CHMP2B antibody) at dilution of 1:1000
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalProbable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and the budding of enveloped viruses (HIV-1 and other lentiviruses). ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.
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Gene nameCHMP2B
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Uniprot IDQ9UQN3
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Observed M.W.32 kDa
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