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Alternative name
CALIF, POP2 antibody
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Catalog
A001812
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC,IP
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PurificationImmunogen affinity purified
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ImmunogenCCR4-NOT transcription complex, subunit 8
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IHCImmunohistochemistry of paraffin-embedded human prostate cancer using A001812(CNOT8 antibody) at dilution of 1:100
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Western BlotJurkat cells were subjected to SDS PAGE followed by western blot with A001812(CNOT8 antibody) at dilution of 1:400
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalHas 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Its function seems to be partially redundant with that of CNOT7. Catalytic component of the CCR4-NOT complex which is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. During miRNA-mediated repression the complex seems also to act as translational repressor during translational initiation. Additional complex functions may be a consequence of its influence on mRNA expression. Associates with members of the BTG family such as TOB1 and BTG2 and is required for their anti-proliferative activity.
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Gene nameCNOT8
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Uniprot IDQ9UFF9
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Observed M.W.34 kDa
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