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Alternative name
cereblon, CRBN, DKFZp781K0715, MRT2A, Protein cereblon antibody
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Catalog
A001954
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC,IF
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PurificationImmunogen affinity purified
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Immunogencereblon
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IHCImmunohistochemistry of paraffin-embedded human cervical cancer tissue slide using A001954( CRBN Antibody) at dilution of 1:200
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Western Blotmouse heart tissue were subjected to SDS PAGE followed by western blot with A001954(CRBN antibody) at dilution of 1:1000
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalSubstrate recognition component of a DCX (DDB1-CUL4-X- box) E3 protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as MEIS2. Normal degradation of key regulatory proteins is required for normal limb outgrowth and expression of the fibroblast growth factor FGF8. May play a role in memory and learning by regulating the assembly and neuronal surface expression of large-conductance calcium-activated potassium channels in brain regions involved in memory and learning via its interaction with KCNT1. Binding of pomalidomide and other thalidomide-related drugs changes the substrate specificity of the human protein, leading to decreased degradation of MEIS2 and other target proteins and increased degradation of MYC, IRF4, IKZF1 and IKZF3.
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Gene nameCRBN
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Uniprot IDQ96SW2
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Observed M.W.53 kDa
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