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Alternative name
CP1B, CYP1B1, CYPIB1, Cytochrome P450 1B1, GLC3A, P4501B1 antibody
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Catalog
A002149
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogencytochrome P450, family 1, subfamily B, polypeptide 1
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IHCImmunohistochemistry of paraffin-embedded human colon cancer tissue slide using A002149( CYP1B1 Antibody) at dilution of 1:50
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Western BlotMCF-7 cells were subjected to SDS PAGE followed by western blot with A002149( CYP1B1 Antibody) at dilution of 1:600
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalCytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, retinoid and xenobiotics. Preferentially oxidizes 17beta- estradiol to the carcinogenic 4-hydroxy derivative, and a variety of procarcinogenic compounds to their activated forms, including polycyclic aromatic hydrocarbons. Promotes angiogenesis by removing cellular oxygenation products, thereby decreasing oxidative stress, release of antiangiogenic factor THBS2, then allowing endothelial cells migration, cell adhesion and capillary morphogenesis. These changes are concommitant with the endothelial nitric oxide synthase activity and nitric oxide synthesis. Plays an important role in the regulation of perivascular cell proliferation, migration, and survival through modulation of the intracellular oxidative state and NF-kappa-B expression and/or activity, during angiogenesis. Contributes to oxidative homeostasis and ultrastructural organization and function of trabecular meshwork tissue through modulation of POSTN expression.
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Gene nameCYP1B1
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Uniprot IDQ16678
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Observed M.W.52 kDa
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