-
Alternative name
AGS3, DKFZp727I051, GPSM1 antibody
-
Catalog
A000221
-
Size100μg
-
Formliquid
-
Purity≥95% as determined by SDS-PAGE
-
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
-
ClonalityPolyclonal Antibody
-
Host Rabbit
-
Species ReactivityHuman,Mouse ,Rat
-
Applications Tested/SuitableELISA,IHC,IF,WB
-
PurificationImmunogen affinity purified
-
ImmunogenG-protein signaling modulator 1 (AGS3-like, C. elegans)
-
IHCImmunohistochemistry of paraffin-embedded human lung cancer using A000221(GPSM1 antibody) at dilution of 1:50
-
Western BlotHeLa cells were subjected to SDS PAGE followed by western blot with A000221(GPSM1 antibody) at dilution of 1:600
-
Recommended dilutionWB :1:200-1:2000;IF:1:10-1:100;IHC:1:20-1:200
-
Product Description specificalGPSM1, also named as AGS3, is a receptor-independent G protein activator that has been implicated in multiple biological events such as brain development, neuroplasticity and addiction, cardiac function, Golgi structure/function, macroautophagy and metabolism. It contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. It has been shown that AGS3 could regulate the orientation of the mitotic spindle, cAMP production, membrane protein transport, and asymmetric cell division by binding preferentially to inactive Gai/o subunits complexed with guanine dinucleotide phosphate (GDP) at multiple G-protein regulatory or GoLoco motif repeats. It also plays an important anti-apoptotic role through enhancing the phosphorylation of cyclic AMP response element-binding protein (p-CREB).
-
Gene nameGPSM1
-
locationCell membrane,Cytoplasm,Endoplasmic reticulum,Golgi apparatus,Membrane
-
Uniprot IDQ86YR5
-
Calculated M.W.72kDa
-
Observed M.W.72 kDa
-