-
Alternative name
ERDJ5 antibody
-
Catalog
A002457
-
Size100μg
-
Formliquid
-
Purity≥95% as determined by SDS-PAGE
-
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
-
ClonalityPolyclonal Antibody
-
Host Rabbit
-
Species ReactivityHuman, Mouse ,Rat
-
Applications Tested/SuitableELISA,WB,IHC
-
PurificationImmunogen affinity purified
-
ImmunogenDnaJ (Hsp40) homolog, subfamily C, member 10
-
IHCImmunohistochemistry of paraffin-embedded human pancreas cancer using A002457(DNAJC10 antibody) at dilution of 1:100
-
Western BlotHeLa cells were subjected to SDS PAGE followed by western blot with A002457(DNAJC10 antibody) at dilution of 1:1500
-
Recommended dilutionWB : 1:500-1:5000
-
Product Description specificalEndoplasmic reticulum disulfide reductase involved both in the correct folding of proteins and degradation of misfolded proteins. Required for efficient folding of proteins in the endoplasmic reticulum by catalyzing the removal of non-native disulfide bonds formed during the folding of proteins, such as LDLR. Also involved in endoplasmic reticulum-associated degradation (ERAD) by reducing incorrect disulfide bonds in misfolded glycoproteins recognized by EDEM1. Interaction with HSPA5 is required its activity, not for the disulfide reductase activity, but to facilitate the release of DNAJC10 from its substrate. Promotes apoptotic signaling pathway in response to endoplasmic reticulum stress.
-
Gene nameDNAJC10
-
Uniprot IDQ8IXB1
-
Observed M.W.75-80 kDa
-