-
Alternative name
AATF, CHE 1, CHE1, DED, Protein AATF, Rb binding protein Che 1, Traube antibody
-
Catalog
A000025
-
Size100μg
-
Formliquid
-
Purity≥95% as determined by SDS-PAGE
-
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
-
ClonalityPolyclonal Antibody
-
Host Rabbit
-
Species ReactivityHuman,Mouse ,Rat
-
Applications Tested/SuitableELISA,WB,IF
-
PurificationImmunogen affinity purified
-
Immunogenapoptosis antagonizing transcription factor
-
Western Blotmouse brain tissue were subjected to SDS PAGE followed by western blot with A000025(AATF antibody) at dilution of 1:800
-
Recommended dilutionWB : 1:200-1:2000;IF:1:10-1:100
-
Product Description specificalMay function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.
-
Gene nameAATF
-
locationNucleus
-
Uniprot IDQ9NY61
-
Calculated M.W.63kDa
-
Observed M.W.63kd
-