-
Alternative name
3'EXO, THEX1 antibody
-
Catalog
A002843
-
Size100μg
-
Formliquid
-
Purity≥95% as determined by SDS-PAGE
-
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
-
ClonalityPolyclonal Antibody
-
Host Rabbit
-
Species ReactivityHuman,Mouse ,Rat
-
Applications Tested/SuitableELISA,WB,IHC,IF
-
PurificationImmunogen affinity purified
-
Immunogenexoribonuclease 1
-
IHCImmunohistochemistry of paraffin-embedded human testis using A002843(ERI1 antibody) at dilution of 1:50
-
Western BlotK-562 cells were subjected to SDS PAGE followed by western blot with A002843(ERI1 antibody) at dilution of 1:1000
-
Recommended dilutionWB : 1:500-1:5000
-
Product Description specificalRNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5.8S rRNA 3'-end processing. Also binds to 5.8s ribosomal RNA. Binds with high affinity to the stem-loop structure of replication- dependent histone pre-mRNAs.
-
Gene nameERI1
-
Uniprot IDQ8IV48
-
Observed M.W.46kd
-