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Alternative name
Alpha B Crystallin, Alpha crystallin B chain, Alpha(B) crystallin, CRYA2, CRYAB, crystallin, alpha B, CTPP2, Heat shock protein beta 5, HSPB5, Rosenthal fiber component antibody
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Catalog
A000325
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC,IP
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PurificationImmunogen affinity purified
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Immunogencrystallin, alpha B
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IHCImmunohistochemistry of paraffin-embedded human eye using A000325(CRYAB antibody) at dilution of 1:100
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Western Blothuman heart tissue were subjected to SDS PAGE followed by western blot with A000325(CRYAB antibody) at dilution of 1:500
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Recommended dilutionWB :1:500-1:5000;IHC:1:20-1:200;IP:1:200-1:2000
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Product Description specificalAlpha B-crystallin, encoded by CRYAB gene, is multifunctional, serving as both a major structural protein in the lens and a small heat-shock protein in other tissues in mammals. Alpha B-crystallin may contribute to the transparency and refractive index of the lens. Single nucleotide polymorphisms (SNPs) in the promoter region of CRYAB gene have been associated with in multiple sclerosis. Mutations in the CRYAB gene cause distinct clinical phenotypes including isolated posterior polar cataract, myofibrillar myopathy, cardiomyopathy, or a multisystemic disorder combining all these features. Impairment of alpha-B crystallin dimerization may be relevant to the pathogenesis of these disorders.
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Gene nameCRYAB
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locationCytoplasm,Nucleus
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Uniprot IDP02511
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Calculated M.W.20kDa
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Observed M.W.20-22 kDa
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