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Alternative name
Alpha catenin, Alpha E catenin, Cadherin associated protein, CAP102, Catenin alpha 1, CTNNA1, α-catenin, α-E-catenin, αE-catenin antibody
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Catalog
A000327
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC,IF,FC,IP
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PurificationImmunogen affinity purified
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Immunogencatenin (cadherin-associated protein), alpha 1, 102kDa
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IHCImmunohistochemistry of paraffin-embedded human stomach tissue slide using A000327( CTNNA1 Antibody) at dilution of 1:50
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Western Blotmouse uterus tissue were subjected to SDS PAGE followed by western blot with A000327(CTNNA1 Antibody) at dilution of 1:2000
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Recommended dilutionWB :1:1000-1:10000;IHC:1:20-1:200;IP:1:200-1:2000;IF:1:10-1:100
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Product Description specificalAlpha catenin is an essential component of adherens junctions that connects E-cadherin-β-catenin complexes with the actin cytoskeleton. It also recruits a range of other important proteins to developing intercellular junctions. Three alpha catenins exist in human: alpha-E-catenin, alpha-N-catenin, and alpha-T-catenin, which share substantial amino-acid sequence similarity but have distinct tissue distribution. alpha-E-catenin is ubiquitously expressed, alpha-N-catenin is restricted to neuronal tissue, and alpha-T-catenin is primarily expressed in heart tissue. Reduced levels of alpha-E-catenin protein seem to be characteristic of many different human cancers, including malignant tumours of the breast, colon, stomach, oesophagus, bladder and liver. In addition, the loss of alpha-E-catenin often correlates with the degree of tumour differentiation and metastasis.
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Gene nameCTNNA1
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locationCytoplasm,Cytoskeleton,ell membrane
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Uniprot IDP35221
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Calculated M.W.100kDa
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Observed M.W.100 kDa
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