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Alternative name
Alpha synuclein, NACP, PARK1, PARK4, SNCA antibody
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Catalog
A000345
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,IHC,WB,IF
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PurificationImmunogen affinity purified
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Immunogensynuclein, alpha (non A4 component of amyloid precursor)
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IHCImmunohistochemistry of paraffin-embedded human brain using A000345(SNCA antibody) at dilution of 1:50
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Western Blotmouse brain tissue were subjected to SDS PAGE followed by western blot with A000345(SNCA antibody) at dilution of 1:1000
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Recommended dilutionWB :1:500-1:5000;IF:1:10-1:100;IHC:1:20-1:200
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Product Description specificalSNCA, also named as NACP, PARK1 and Alpha-synuclein, belongs to the synuclein family. It may be involved in the regulation of dopamine release and transport. SNCA reduces neuronal responsiveness to various apoptotic stimuli, leading to a decreased caspase-3 activation. The deposition of aggregated SNCa is the pathological hallmark of Lewy body disease, which includes Parkinson's disease (PD), diffuse Lewy body disease (DLBD), and Lewy body variant of Alzheimer's disease (LBV).(PMID:21056999) This antibody can recognize all the isoforms of SNCA.
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Gene nameSNCA
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locationwidely
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Uniprot IDP37840
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Calculated M.W.14kDa,observed 19kDa
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Observed M.W.15-19 kDa
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