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Alternative name
FLJ33952, G protein coupled receptor 161, G protein coupled receptor RE2, GPR161, RE2 antibody
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Catalog
A003598
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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ImmunogenG protein-coupled receptor 161
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IHCImmunohistochemistry of paraffin-embedded human placenta using A003598(GPR161 antibody) at dilution of 1:50
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Western BlotHeLa cells were subjected to SDS PAGE followed by western blot with A003598(GPR161 antibody) at dilution of 1:500
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalKey negative regulator of Shh signaling, which promotes the processing of GLI3 into GLI3R during neural tube development. Recruited by TULP3 and the IFT-A complex to primary cilia and acts as a regulator of the PKA-dependent basal repression machinery in Shh signaling by increasing cAMP levels, leading to promote the PKA-dependent processing of GLI3 into GLI3R and repress the Shh signaling. In presence of SHH, it is removed from primary cilia and is internalized into recycling endosomes, preventing its activity and allowing activation of the Shh signaling. Its ligand is unknown (By similarity).
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Gene nameGPR161
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Uniprot IDQ8N6U8
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Observed M.W.70 kDa
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