-
Alternative name
KIAA1320 antibody
-
Catalog
A003745
-
Size100μg
-
Formliquid
-
Purity≥95% as determined by SDS-PAGE
-
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
-
ClonalityPolyclonal Antibody
-
Host Rabbit
-
Species ReactivityHuman
-
Applications Tested/SuitableELISA,WB,IF
-
PurificationImmunogen affinity purified
-
ImmunogenHECT domain and ankyrin repeat containing, E3 ubiquitin protein ligase 1
-
Recommended dilutionWB : 1:200-1:2000
-
Product Description specificalE3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
-
Gene nameHACE1
-
Uniprot IDQ8IYU2
-
Observed M.W.78 kDa
-