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Alternative name
BHLHB31, CHF2, HERP2, HESR1, HRT1 antibody
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Catalog
A003849
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC,IP
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PurificationImmunogen affinity purified
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Immunogenhairy/enhancer-of-split related with YRPW motif 1
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IHCImmunohistochemistry of paraffin-embedded human brain using A003849(HEY1 antibody) at dilution of 1:100
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Western BlotDU 145 cells were subjected to SDS PAGE followed by western blot with A003849(HEY1 antibody) at dilution of 1:3000
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalTranscriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGTG-3' (PubMed:11095750). Downstream effector of Notch signaling required for cardiovascular development. Specifically required for the Notch-induced endocardial epithelial to mesenchymal transition, which is itself criticial for cardiac valve and septum development. May be required in conjunction with HEY2 to specify arterial cell fate or identity. Promotes maintenance of neuronal precursor cells and glial versus neuronal fate specification. Represses transcription by the cardiac transcriptional activators GATA4 and GATA6 and by the neuronal bHLH factors ASCL1/MASH1 and NEUROD4/MATH3 (PubMed:15485867). Involved in the regulation of liver cancer cells self-renewal (PubMed:25985737).
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Gene nameHEY1
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Uniprot IDQ9Y5J3
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Observed M.W.32-34 kDa
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