-
Alternative name
HTRA, PRSS11 antibody
-
Catalog
A004069
-
Size100μg
-
Formliquid
-
Purity≥95% as determined by SDS-PAGE
-
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
-
ClonalityPolyclonal Antibody
-
Host Rabbit
-
Species ReactivityHuman,Mouse ,Rat
-
Applications Tested/SuitableELISA,WB,IF,IP,IHC
-
PurificationImmunogen affinity purified
-
ImmunogenHtrA serine peptidase 1
-
IHCImmunohistochemistry of paraffin-embedded human placenta tissue slide using A004069( HTRA1 Antibody) at dilution of 1:200
-
Western BlotL02 cells were subjected to SDS PAGE followed by western blot with A004069(HTRA1 antibody) at dilution of 1:600
-
Recommended dilutionWB : 1:500-1:5000
-
Product Description specificalSerine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets.
-
Gene nameHTRA1
-
Uniprot IDQ92743
-
Observed M.W.35 kDa, 50 kD, 42 kDa
-