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Alternative name
Demethylase, DKFZp586O0821, DMTase, MBD2, NY CO 41 antibody
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Catalog
A005034
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Rat
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Applications Tested/SuitableELISA,WB
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PurificationImmunogen affinity purified
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Immunogenmethyl-CpG binding domain protein 2
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalBinds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.
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Gene nameMBD2
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Uniprot IDQ9UBB5
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Observed M.W.43-45 kDa
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