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Alternative name
DKFZp762O1615, FLJ38893, FLJ46755, MCC, MCC1, mutated in colorectal cancers, Protein MCC antibody
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Catalog
A005046
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,IHC,IP,WB,IF
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PurificationImmunogen affinity purified
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Immunogenmutated in colorectal cancers
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IHCImmunohistochemistry of paraffin-embedded human prostate cancer using A005046(MCC antibody) at dilution of 1:100
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Western Blothuman brain tissue were subjected to SDS PAGE followed by western blot with A005046(MCC antibody) at dilution of 1:500
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalCandidate for the putative colorectal tumor suppressor gene located at 5q21. Suppresses cell proliferation and the Wnt/b- catenin pathway in colorectal cancer cells. Inhibits DNA binding of b-catenin/TCF/LEF transcription factors. Involved in cell migration independently of RAC1, CDC42 and p21-activated kinase (PAK) activation (PubMed:18591935, PubMed:19555689, PubMed:22480440). Represses the beta-catenin pathway (canonical Wnt signaling pathway) in a CCAR2-dependent manner by sequestering CCAR2 to the cytoplasm, thereby impairing its ability to inhibit SIRT1 which is involved in the deacetylation and negative regulation of beta-catenin (CTNB1) transcriptional activity (PubMed:24824780).
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Gene nameMCC
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Uniprot IDP23508
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Observed M.W.98 kDa; 113-118 kDa
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