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Alternative name
MEF2C, myocyte enhancer factor 2C antibody
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Catalog
A005105
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogenmyocyte enhancer factor 2C
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IHCImmunohistochemistry of paraffin-embedded human brain using A005105(MEF2C antibody) at dilution of 1:50
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Western Blotmouse cerebellum tissue were subjected to SDS PAGE followed by western blot with A005105(MEF2C antibody) at dilution of 1:300
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalTranscription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle- specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoform 3 and isoform 4, which lack the repressor domain, are more active than isoform 1 and isoform 2.
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Gene nameMEF2C
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Uniprot IDQ06413
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Observed M.W.51 kDa
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