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Alternative name
ARHGAP18, FLJ25728, MacGAP, bA307O14.2 antibody
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Catalog
A000548
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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ImmunogenRho GTPase activating protein 18
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IHCImmunohistochemistry of paraffin-embedded human kidney using A000548(ARHGAP18 antibody) at dilution of 1:25
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Western BlotPC-3 cells were subjected to SDS PAGE followed by western blot with A000548(ARHGAP18 antibody) at dilution of 1:400
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalRho GTPase activating protein that suppresses F-actin polymerization by inhibiting Rho. Rho GTPase activating proteins act by converting Rho-type GTPases to an inactive GDP-bound state (PubMed:21865595). Plays a key role in tissue tension and 3D tissue shape by regulating cortical actomyosin network formation. Acts downstream of YAP1 and inhibits actin polymerization, which in turn reduces nuclear localization of YAP1 (PubMed:25778702). Regulates cell shape, spreading, and migration (PubMed:21865595).
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Gene nameARHGAP18
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Uniprot IDQ8N392
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Observed M.W.75kd
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