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Alternative name
MLC2 antibody
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Catalog
A005486
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse ,Rat
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Applications Tested/SuitableELISA,IHC,WB
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PurificationImmunogen affinity purified
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Immunogenmyosin, light chain 2, regulatory, cardiac, slow
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IHCImmunohistochemistry of paraffin-embedded human heart tissue slide using A005486( MYL2 Antibody) at dilution of 1:50
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Western Blotrat heart tissue were subjected to SDS PAGE followed by western blot with A005486( MYL2 Antibody) at dilution of 1:5000
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Recommended dilutionWB : 1:2000-1:20000
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Product Description specificalContractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity).
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Gene nameMYL2
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Uniprot IDP10916
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Observed M.W.18-20 kDa
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