anti-NGEF antibody

Alternative name
EPHEXIN, Ephexin 1, NGEF antibody
Catalog
A005720
Size100μg
Formliquid
Purity≥95% as determined by SDS-PAGE
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
ClonalityPolyclonal Antibody
Host Rabbit
Species ReactivityHuman, Mouse
Applications Tested/SuitableELISA,WB,IP
PurificationImmunogen affinity purified
Immunogenneuronal guanine nucleotide exchange factor
Recommended dilutionWB : 1:200-1:2000
Product Description specificalActs as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity).
Gene nameNGEF
Uniprot IDQ8N5V2
Observed M.W.75 kDa

EPHEXIN, Ephexin 1, NGEF antibody