-
Alternative name
CADASIL, CASIL, Notch 3, Notch homolog 3 (Drosophila), NOTCH3 antibody
-
Catalog
A005800
-
Size100μg
-
Formliquid
-
Purity≥95% as determined by SDS-PAGE
-
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
-
ClonalityPolyclonal Antibody
-
Host Rabbit
-
Species ReactivityHuman,Mouse ,Rat
-
Applications Tested/SuitableELISA,WB,IHC,IP
-
PurificationImmunogen affinity purified
-
ImmunogenNotch homolog 3 (Drosophila)
-
IHCImmunohistochemistry of paraffin-embedded human lung cancer tissue slide using A005800( NOTCH3 Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
-
Western BlotCOLO 320 cells were subjected to SDS PAGE followed by western blot with A005800(NOTCH3 antibody) at dilution of 1:500
-
Recommended dilutionWB : 1:500-1:5000
-
Product Description specificalFunctions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus. Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity).
-
Gene nameNOTCH3
-
Uniprot IDQ9UM47
-
Observed M.W.250-260 kDa, 100 kDa
-