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Alternative name
TR2 antibody
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Catalog
A005840
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogennuclear receptor subfamily 2, group C, member 1
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IHCImmunohistochemistry of paraffin-embedded human prostate cancer using A005840(NR2C1 antibody) at dilution of 1:50 Heat mediated antigen retrieved with Citric acid buffer, pH6.0
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Western BlotSH-SY5Y cells were subjected to SDS PAGE followed by western blot with A005840(NR2C1 antibody) at dilution of 1:500
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalOrphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid- regulated preadipocyte proliferation.
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Gene nameNR2C1
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Uniprot IDP13056
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Observed M.W.52kd
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