-
Alternative name
OIAS antibody
-
Catalog
A005949
-
Size100μg
-
Formliquid
-
Purity≥95% as determined by SDS-PAGE
-
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
-
ClonalityPolyclonal Antibody
-
Host Rabbit
-
Species ReactivityHuman,Mouse ,Rat
-
Applications Tested/SuitableELISA,WB,IHC
-
PurificationImmunogen affinity purified
-
Immunogen2',5'-oligoadenylate synthetase 1, 40/46kDa
-
IHCImmunohistochemistry of paraffin-embedded human liver tissue slide using A005949( OAS1 Antibody) at dilution of 1:200
-
Western BlotHeLa cells were subjected to SDS PAGE followed by western blot with A005949(OAS1 antibody) at dilution of 1:500
-
Recommended dilutionWB : 1:500-1:5000
-
Product Description specificalInterferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes higher oligomers of 2'-5'-oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. The secreted form displays antiviral effect against vesicular stomatitis virus (VSV), herpes simplex virus type 2 (HSV-2), and encephalomyocarditis virus (EMCV) and stimulates the alternative antiviral pathway independent of RNase L.
-
Gene nameOAS1
-
Uniprot IDP00973
-
Observed M.W.48 kDa
-