-
Alternative name
(2 5)oligo(A) synthase 3, 2 5 oligoadenylate synthase 3, 2 5A synthase 3, OAS3, p100, p100 OAS, p100OAS antibody
-
Catalog
A005952
-
Size100μg
-
Formliquid
-
Purity≥95% as determined by SDS-PAGE
-
StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
-
ClonalityPolyclonal Antibody
-
Host Rabbit
-
Species ReactivityHuman
-
Applications Tested/SuitableELISA,WB,IHC,IF
-
PurificationImmunogen affinity purified
-
Immunogen2'-5'-oligoadenylate synthetase 3, 100kDa
-
IHCImmunohistochemistry of paraffin-embedded human skin cancer tissue slide using A005952( OAS3 Antibody) at dilution of 1:50
-
Western BlotA375 cells were subjected to SDS PAGE followed by western blot with A005952(OAS3 antibody) at dilution of 1:800
-
Recommended dilutionWB : 1:200-1:2000
-
Product Description specificalInterferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. In addition, it may also play a role in other cellular processes such as apoptosis, cell growth, differentiation and gene regulation. Synthesizes preferentially dimers of 2'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNase L) leading to its dimerization and subsequent activation. Activation of RNase L leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antiviral effect via the classical RNase L-dependent pathway or an alternative antiviral pathway independent of RNase L. Displays antiviral activity against Chikungunya virus (CHIKV), Dengue virus, Sindbis virus (SINV) and Semliki forest virus (SFV).
-
Gene nameOAS3
-
Uniprot IDQ9Y6K5
-
Observed M.W.100 kDa
-