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Alternative name
PAK5 antibody
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Catalog
A006124
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogenp21 protein (Cdc42/Rac)-activated kinase 6
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IHCImmunohistochemistry of paraffin-embedded human prostate cancer using A006124(PAK6 antibody) at dilution of 1:100
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Western BlotPC-3 cells were subjected to SDS PAGE followed by western blot with A006124(PAK6 antibody) at dilution of 1:400
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalSerine/threonine protein kinase that plays a role in the regulation of gene transcription. The kinase activity is induced by various effectors including AR or MAP2K6/MAPKK6. Phosphorylates the DNA-binding domain of androgen receptor/AR and thereby inhibits AR-mediated transcription. Inhibits also ESR1-mediated transcription. May play a role in cytoskeleton regulation by interacting with IQGAP1. May protect cells from apoptosis through phosphorylation of BAD.
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Gene namePAK6
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Uniprot IDQ9NQU5
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Observed M.W.60 kDa
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