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Alternative name
PAR4 antibody
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Catalog
A006166
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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ImmunogenPRKC, apoptosis, WT1, regulator
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IHCImmunohistochemistry of paraffin-embedded human kidney slide using A006166( PAWR Antibody) at dilution of 1:50
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Western Blotmouse heart tissue were subjected to SDS PAGE followed by western blot with A006166(PAWR antibody) at dilution of 1:400
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalPro-apoptopic protein capable of selectively inducing apoptosis in cancer cells, sensitizing the cells to diverse apoptotic stimuli and causing regression of tumors in animal models. Induces apoptosis in certain cancer cells by activation of the Fas prodeath pathway and coparallel inhibition of NF-kappa-B transcriptional activity. Inhibits the transcriptional activation and augments the transcriptional repression mediated by WT1. Down- regulates the anti-apoptotic protein BCL2 via its interaction with WT1. Seems also to be a transcriptional repressor by itself. May be directly involved in regulating the amyloid precursor protein (APP) cleavage activity of BACE1.
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Gene namePAWR
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Uniprot IDQ96IZ0
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Observed M.W.45kd
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