Product Categories
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Alternative name
Protein Ric 8A, RIC8, RIC8A, synembryn, Synembryn A antibody
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Catalog
A007295
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogenresistance to inhibitors of cholinesterase 8 homolog A (C. elegans)
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IHCImmunohistochemistry of paraffin-embedded human pancreas cancer using A007295(RIC8A antibody) at dilution of 1:50
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Western Blothuman brain tissue were subjected to SDS PAGE followed by western blot with A007295(RIC8A antibody) at dilution of 1:200
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalGuanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins. Able to activate GNAI1, GNAO1 and GNAQ, but not GNAS by exchanging bound GDP for free GTP. Involved in regulation of microtubule pulling forces during mitotic movement of chromosomes by stimulating G(i)-alpha protein, possibly leading to release G(i)-alpha-GTP and NuMA proteins from the NuMA-GPSM2-G(i)-alpha-GDP complex (By similarity). Also acts as an activator for G(q)-alpha (GNAQ) protein by enhancing the G(q)-coupled receptor-mediated ERK activation.
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Gene nameRIC8A
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Uniprot IDQ9NPQ8
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Observed M.W.58-62kd
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