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Alternative name
AML1T1, CBFA2T1, CDR, ETO, MTG8, ZMYND2 antibody
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Catalog
A007535
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogenrunt-related transcription factor 1; translocated to, 1 (cyclin D-related)
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IHCImmunohistochemistry of paraffin-embedded mouse brain tissue slide using A007535( RUNX1T1 Antibody) at dilution of 1:50
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Western BlotHepG2 cells were subjected to SDS PAGE followed by western blot with A007535(RUNX1T1 antibody) at dilution of 1:600
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalTranscriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199). Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453). Can repress transactivation mediated by TCF12 (PubMed:16803958). Acts as a negative regulator of adipogenesis (By similarity). The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588).
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Gene nameRUNX1T1
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Uniprot IDQ06455
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Observed M.W.70-80 kDa
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