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Alternative name
SELN antibody
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Catalog
A007716
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogenselenoprotein N, 1
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IHCImmunohistochemistry of paraffin-embedded human heart tissue slide using A007716( SEPN1 Antibody) at dilution of 1:50
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Western BlotA549 cells were subjected to SDS PAGE followed by western blot with A007716( SEPN1 Antibody) at dilution of 1:300
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Recommended dilutionWB : 1:200-1:1000
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Product Description specificalIsoform 2: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (- SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed:19557870, PubMed:18713863). _x000D_Essential for muscle regeneration and satellite cell maintenance in skeletal muscle (PubMed:21131290).
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Gene nameSEPN1
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Uniprot IDQ9NZV5
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Observed M.W.70 kDa
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