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Alternative name
ACD, PIP1, PTOP, TINT1, TPP1 antibody
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Catalog
A000078
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman
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Applications Tested/SuitableELISA,WB
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PurificationImmunogen affinity purified
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Immunogenadrenocortical dysplasia homolog ( Mouse )
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Western BlotJurkat cells were subjected to SDS PAGE followed by western blot with A000078( ACD Antibody) at dilution of 1:1500
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Recommended dilutionWB :1:500-1:5000
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Product Description specificalComponent of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis.
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Gene nameACD
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locationChromosome,Nucleus,Telomere
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Uniprot IDQ96AP0
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Calculated M.W.58kDa
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Observed M.W.57-60 kDa
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