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Alternative name
BACE, KIAA1149 antibody
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Catalog
A000781
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse , Zebrafish
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Applications Tested/SuitableELISA,WB,IP,IHC
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PurificationImmunogen affinity purified
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Immunogenbeta-site APP-cleaving enzyme 1
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IHCImmunohistochemistry of paraffin-embedded mouse brain tissue slide using A000781( BACE1 Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).
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Western Blotmouse brain tissue were subjected to SDS PAGE followed by western blot with A000781(BACE1 antibody) at dilution of 1:500
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalResponsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase.
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Gene nameBACE1
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Uniprot IDP56817
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Observed M.W.70-75 kDa
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