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Alternative name
FISH, KIAA0418, SH3MD1, TKS5 antibody
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Catalog
A007836
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC,IF
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PurificationImmunogen affinity purified
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ImmunogenSH3 and PX domains 2A
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IHCImmunohistochemistry of paraffin-embedded human breast cancer using A007836(SH3PXD2A antibody) at dilution of 1:50
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Western BlotHeLa cells were subjected to SDS PAGE followed by western blot with A007836(SH3PXD2A antibody) at dilution of 1:500
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalAdapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of beta-amyloid peptide.
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Gene nameSH3PXD2A
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Uniprot IDQ5TCZ1
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Observed M.W.140-150 kDa
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