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Alternative name
GLYA, Serine methylase, SHMT, SHMT2 antibody
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Catalog
A007851
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC,IF
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PurificationImmunogen affinity purified
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Immunogenserine hydroxymethyltransferase 2 (mitochondrial)
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IHCImmunohistochemistry of paraffin-embedded human cervical cancer using A007851(SHMT2 antibody) at dilution of 1:50
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Western BlotHeLa cells were subjected to SDS PAGE followed by western blot with A007851(SHMT2 antibody) at dilution of 1:800
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Recommended dilutionWB : 1:200-1:2000
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Product Description specificalContributes to the de novo mitochondrial thymidylate biosynthesis pathway via its role in glycine and tetrahydrofolate metabolism. Thymidylate biosynthesis is required to prevent uracil accumulation in mtDNA (PubMed:21876188). Interconversion of serine and glycine (PubMed:25619277). Associates with mitochondrial DNA (PubMed:18063578). Plays a role in the deubiquitination of target proteins as component of the BRISC complex (PubMed:24075985). Required for IFNAR1 deubiquitination by the BRISC complex (PubMed:24075985).
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Gene nameSHMT2
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Uniprot IDP34897
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Observed M.W.55 kDa
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