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Alternative name
PTHB1 antibody
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Catalog
A000825
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman, Mouse
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Applications Tested/SuitableELISA,IHC,IF,WB,IP
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PurificationImmunogen affinity purified
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ImmunogenBardet-Biedl syndrome 9
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IHCImmunohistochemistry of paraffin-embedded human liver using A000825(BBS9 antibody) at dilution of 1:50
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Western Blotmouse testis tissue were subjected to SDS PAGE followed by western blot with A000825(BBS9 antibody) at dilution of 1:300
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Recommended dilutionWB : 1:200-1:1000
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Product Description specificalThe BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. This ciliogenic function is mediated in part by the Rab8 GDP/GTP exchange factor, which localizes to the basal body and contacts the BBSome. Rab8(GTP) enters the primary cilium and promotes extension of the ciliary membrane. Firstly the BBSome associates with the ciliary membrane and binds to RAB3IP/Rabin8, the guanosyl exchange factor (GEF) for Rab8 and then the Rab8-GTP localizes to the cilium and promotes docking and fusion of carrier vesicles to the base of the ciliary membrane. Required for proper BBSome complex assembly and its ciliary localization.
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Gene nameBBS9
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Uniprot IDQ3SYG4
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Observed M.W.60 kDa
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