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Alternative name
KIAA0210 antibody
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Catalog
A008515
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC,IP
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PurificationImmunogen affinity purified
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ImmunogenTBC1 domain family, member 5
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IHCImmunohistochemistry of paraffin-embedded human kidney using A008515(TBC1D5 antibody) at dilution of 1:100
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Western BlotA431 cells were subjected to SDS PAGE followed by western blot with A008515(TBC1D5 antibody) at dilution of 1:400
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalMay act as a GTPase-activating protein (GAP) for Rab family protein(s). May act as a GAP for RAB7A. Can displace RAB7A and retromer CSC subcomplex from the endosomal membrane to the cytosol; at least retromer displacement seems to require its catalytic activity (PubMed:19531583, PubMed:20923837). Required for retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN); the function seems to require its catalytic activity. Involved in regulation of autophagy (PubMed:22354992). May act as a molecular switch between endosomal and autophagosomal transport and is involved in reprogramming vesicle trafficking upon autophagy induction. Involved in the trafficking of ATG9A upon activation of autophagy. May regulate the recruitment of ATG9A-AP2-containing vesicles to autophagic membranes (PubMed:24603492).
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Gene nameTBC1D5
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Uniprot IDQ92609
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Observed M.W.89 kDa
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