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Alternative name
EloC, Elongin 15 kDa subunit, Elongin C, SIII, SIII p15, TCEB1 antibody
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Catalog
A008548
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IHC
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PurificationImmunogen affinity purified
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Immunogentranscription elongation factor B (SIII), polypeptide 1 (15kDa, elongin C)
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IHCImmunohistochemistry of paraffin-embedded human breast cancer using A008548(TCEB1 antibody) at dilution of 1:50
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Western Blotmouse testis tissue were subjected to SDS PAGE followed by western blot with A008548(TCEB1 antibody) at dilution of 1:300
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Recommended dilutionWB : 1:500-1:5000
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Product Description specificalSIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A is transcriptionally active and its transcription activity is strongly enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex). _x000D_The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC- box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.
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Gene nameTCEB1
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Uniprot IDQ15369
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Observed M.W.12 kDa
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