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Alternative name
DRIP5, RAP1 antibody
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Catalog
A008599
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Size100μg
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Formliquid
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Purity≥95% as determined by SDS-PAGE
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StoragePBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20℃ for 24 months (Avoid repeated freeze / thaw cycles.)
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ClonalityPolyclonal Antibody
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Host Rabbit
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Species ReactivityHuman,Mouse ,Rat
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Applications Tested/SuitableELISA,WB,IF,IHC,IP,FC
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PurificationImmunogen affinity purified
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Immunogentelomeric repeat binding factor 2, interacting protein
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IHCImmunohistochemistry of paraffin-embedded human tonsillitis tissue slide using A008599( TERF2IP Antibody) at dilution of 1:50
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Western BlotA431 cells were subjected to SDS PAGE followed by western blot with A008599(TERF2IP antibody) at dilution of 1:800
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Recommended dilutionWB : 1:1000-1:10000
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Product Description specificalActs both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'- TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.
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Gene nameTERF2IP
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Uniprot IDQ9NYB0
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Observed M.W.60kd
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